Damage: 2.62 (growing to 3.5 with 1 x Full Heart remaining).To access Eve, you must complete a task in which you must not pick up any hearts for two levels in a row, implying that you are cautious of receiving damage.
Because this is rare to happen organically in a run, your best bet is to try your luck at the slot machines if you come across one. Cain may only be unlocked by holding 55 coins at once. Unlocking Cain is another simple task, but it does need a consistent level of luck over the course of a run. This will be a difficult task for Lazarus because he was much weaker in his first life. Without losing a life, you must run all the way to Mom’s Heart/It Lives and defeat it. Playing as Lazarus on Binding Of Isaac’s hard mode unlocks Bethany. Take the two key pieces to the Dark Room or Chest, and the door will immediately unlock, allowing you to vanquish Mega Satan and unlock Apollyon. 
The fights are started by bombing the angel statue in the center of the room.
To be able to unlock them After that, you must obtain two Angel Rooms and beat the Angel boss inside those two. First, when playing as ?, you must defeat The Lamb. To open this door, you must combine two crucial components, both of which are difficult to open. Mega Satan is located on the same floor as The Lamb but is hidden behind the giant locked golden door in the floor’s starting area. You must battle Mega Satan in order to unlock Apollyon. A Devil Room must spawn at least once in a run, and you must have enough heart containers to sacrifice in order to accept the offers. Azazel can be unlocked by making three bargains with the Devil in a single run. 
Screengrab Courtesy of 2 Left Thumbs via YouTube Name There are numerous objects and characters to discover, some of which are quite tough to obtain. With the release of Repentance – the conclusion of The Binding of Isaac now is a fantastic moment to dive into the game for the first time and play through the complete adventure from beginning to end. What began as a simple game quickly grew in popularity, prompting the creator to produce tons of DLC.
The Binding of Isaac is unquestionably one of the most enjoyable, exciting, and in-depth Indie releases.
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